While most likely idiosyncratic to the specific guitar, I had a (BOOMY) wolf note at the low E through my Anthem.

Turning the bass knob all the way down on both the Venue pre-amp and the amp or pa itself didn't do the job. Tried adjusting the balance between the two signals, boosting the trebles etc. Yuk!

Then, I turned the second knob on the Venue EQ (the sweep from 100 to 2500 db's) all the way down to 100 and cut it to about 1/8 strength.

Solved.

Bass knob and everyone else comes back to flat. This allows other nearby bass frequencies to join in, the trebles to return from Stratocasterland, and the fun begins again.

Cheers,

Brent